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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may perhaps result in a rise in methadone plasma concentrations, which could result in most likely deadly respiratory melancholy. In addition, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also result in a rise